![]() In many cases, Wernicke-Korsakoff syndrome, a prototypical example of amnestic syndrome, retrograde amnesia can extend up to 20 years before the onset of the disease. ![]() This temporary gradient is not always observed and its intensity is influenced by very different factors, among which stand out the location and extent of brain damage. With a temporary gradientįrequently retrograde amnesia has a clear time gradient: memories of the remote past tend to be preserved to a greater extent than the most recent This has been attributed to the fact that the nervous system requires a long period of time to consolidate a memory definitively through the formation of cortical connections. This criterion is one of the most relevant in the classification of retrograde amnesias, together with the causes of the alteration and the specific characteristics of the deficits.
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